Parkinson’s disease is a movement disorder which occurs in about 1% of the general population above 55 years of age. It manifests as selective damage to the dopaminergic neurons, which are situated in the nigro-striatal region of the brain and leads to motor-deficits which includes rigidity, tremors, dementia, frequent falls, and freezing of gait in the later stages. Dopamine replacement therapy is the most commonly used treatment strategy against PD. However it provides only symptomatic relief and the disease progresses inevitably. Also, as the time goes by, it loses its efficacy along with a substantial increase in the side effects. That being said, it becomes crucial to develop an interventional strategy, which can effectively retard, halt or even reverse the process of disease progression. In this regard, the epidemiological studies over the past 50 years [… Read More]
Parkinson disease is a gradually progressive neurodegenerative disorder affecting the dopaminergic neurons in the nigrostriatal region of the brain. Damage to the nigro striatal region leads to a loss of dopaminergic neurons, which leads to slowing of the movements, tremors, rigidity, lack of muscle control and coordination, and freezing of gait in the advanced stages. The disease affects millions of people worldwide annually, and is very difficult to diagnose and cure because of the overlapping atypical Parkinsonian syndromes. Keeping this in mind, the Stem cell therapy is growing in popularity globally particularly for neurological disorders and neurodegenerative diseases like Parkinson’s disease. Researchers have confirmed the possibility of development of dopaminergic neurons from human embryonic stem cells, which have the potential to become any cell of the body. Clinics offering stem cell therapy are now [… Read More]
Parkinson’s disease is a common neurodegenerative disorder characterized by selective loss of nigro-striatal dopaminergic neurons, which manifests as motor deficits in the form of tremors, rigidity, lack of muscle movements and coordination, frequent falls and freezing of gait. Pathophysiology, diagnosis, and treatment of PD is currently one of the most studied and researched subject. The treatment options available can only ease the quality of life, but cannot halt or retard the inevitable progression of disease. One of the latest medico-technological advancement in the field of parkinson’s research is the advent of pluripotent stem cell technology as means of therapeutic intervention. Although in the early stages, the potential use of induced pluripotent stem cells (iPSCs) in the treatment of Parkinson’s disease (PD) holds tremendous possibilities for the future. A significant amount of research is still necessary [… Read More]
Significant research and several clinical trials have been done regarding the efficacy of gene therapy in Parkinson’s disease (PD). While many claims have been made involving numerous wonder cures for PD, gene therapy may hold the exciting possibility of not only delaying disease progression but also halting it completely. Limitations in the efficacy and success of various medical and surgical procedures, have stimulated the scientists all over the world to explore the possibility of Parkinson’s cure through gene therapy. Parkinson’s disease is a progressive neurodegenerative disorder where there is steady loss of brain cells of the substantia nigra involved in the production of the chemical neurotransmitter dopamine. The gene therapy approach has a distinct advantage as it might offer new hopes to preserve or restore the damaged dopaminergic neurons through the use of brain growth [… Read More]
Parkinson’s disease is one of the most common neurological degenerative disorder of the central nervous system causing serious disability due to the loss of dopaminergic neurons in the substantia nigra region of brain. Surgery may be contemplated in a Parkinson’s disease patient either to control symptoms of the disease or for some cause unrelated to Parkinson’s disease, such as a hip replacement, a broken shoulder or prostate gland removal. The risks associated with surgery need to be analyzed so as to decide whether the benefits outweigh the risks and if surgery is justifiable in such patients. Considerations such as age of the patient, type of surgery, and the stage of Parkinson’s disease should be kept in mind before arriving at a decision. Deep brain stimulation is the most common surgical procedure adopted for Parkinson’s Disease. [… Read More]
Parkinson’s disease the chronic neurodegenerative disorder with progressive is caused due to the deficiency of chemical neurotransmitter dopamine. This dopamine deficiency is the result of insult or injury to the nigrostriatal region of the brain. People with Parkinson’s experience a myriad of premotor and motor symptoms including tremors, stiffness, rigidity, slowness of movements, frequent falls and freezing of gait Due to the absence of any specific disease modifying cure, the mainstay of the therapeutic treatment against Parkinson’s disease lies in the dopamine replacement. Parkinson’s patients may also seek relief from their symptoms using various types of complementary medicines. Scientists all over the world have done various researches which have lead to the evolution of our understanding towards the Parkinson’s disease in terms of both diagnosis as well as treatment. These therapies support or complement the [… Read More]
Parkinson’s disease is the chronic progressive neurodegenerative disorder that robs you of the ability to control your own body. It presents with a myriad of symptoms which exhibit varying degrees of motor impairment including tremors, rigidity, stiffness, and loss of muscle control and coordination. Parkinson’s disease medicines can be expensive and the financial impact can be devastating in the long term, especially if health insurance is an issue. It is not uncommon for any chronic disease sufferer to seek alternate sources, especially if the more expensive branded medicine may be available at a cheaper rate. However, the possibility should be kept in mind that the drug obtained from such sources is cheaper because it is a counterfeit or fake. Counterfeit medicines are falsified sub-standard medicines and deliberately appears to be a genuine as well as [… Read More]
Parkinson’s disease patients, like any other patient, may take an overdose of their prescribed medicines either accidentally or intentionally. A drug dose that is high enough to cause harmful effects on the body is considered as an overdose. Taking more than his prescribed dose of any medicine can affect each individual differently and the effect will also depend upon the type of medicine ingested as well as the quantity. Varying effects may be seen when the medicine is combined with other drugs, alcohol, or if it is taken along with food or on an empty stomach.
Parkinson’s disease is a long term disease where the patient needs to take medicines on a regular basis for relief of the symptoms> It is important for both the Parkinson’s patient and care givers to realize that these medicines might have various types of interactions with other drugs. Some of these drug interactions can be quite severe, therefore additional medicines should be taken only after consulting a doctor.
Parkinson’s disease is a degenerative disease of the brain where there is progressive depletion of dopamine producing neurons in the substantia nigra, located in the brain. Stem cell therapy may possibly offer a solution as it aims at treating this disease by growing new cells to replace the older degenerated ones.