Parkinson’s disease is a neurodegenerative disease characterized by a gradual and progressive loss of dopamine nerve cells (dopaminergic neurons) in the substantia nigra region of brain. Dopamine loss is the characteristic hallmark of the disease and is the main culprit behind the signs and symptoms and complications associated with it. Although there is no specific test for Parkinson’s disease, and the accuracy of clinical diagnosis of parkinsonism is still limited, however recent advances in a diagnostic imaging technique known as SPECT molecular imaging technique, may help doctors identify high risk patients even before the symptoms of Parkinson’s disease appear. It may also serve as a tool to monitor the disease progression. Currently Parkinson’s disease is identified by a clinical diagnosis where the medical history and clinical presentation allows a doctor to reach the diagnosis. However, [… Read More]
Parkinson’s disease is a movement disorder which occurs in about 1% of the general population above 55 years of age. It manifests as selective damage to the dopaminergic neurons, which are situated in the nigro-striatal region of the brain and leads to motor-deficits which includes rigidity, tremors, dementia, frequent falls, and freezing of gait in the later stages. Dopamine replacement therapy is the most commonly used treatment strategy against PD. However it provides only symptomatic relief and the disease progresses inevitably. Also, as the time goes by, it loses its efficacy along with a substantial increase in the side effects. That being said, it becomes crucial to develop an interventional strategy, which can effectively retard, halt or even reverse the process of disease progression. In this regard, the epidemiological studies over the past 50 years [… Read More]
Parkinson’s disease or PD is a neurodegenerative disease which means that nervous dysfunction is gradual and progressive. In other words, it develops slowly and gets worse over time, affecting approximately 5 million people throughout the world. It is one of the diseases involving extensive ongoing research in the diagnostic and therapeutic areas. Most PD patients only discover the condition once signs and symptoms, usually those affecting movement, become obvious and affect daily functioning to a level that they need to seek medical advice. However, there are methods to diagnose Parkinson’s disease in the early stages when a person has no signs or symptoms (asymptomatic) or when it is too mild to be evident either to the patient or doctor. These diagnostic tests should be conducted routinely on patients who are possibly at risk, like those [… Read More]
Parkinson disease is a gradually progressive neurodegenerative disorder affecting the dopaminergic neurons in the nigrostriatal region of the brain. Damage to the nigro striatal region leads to a loss of dopaminergic neurons, which leads to slowing of the movements, tremors, rigidity, lack of muscle control and coordination, and freezing of gait in the advanced stages. The disease affects millions of people worldwide annually, and is very difficult to diagnose and cure because of the overlapping atypical Parkinsonian syndromes. Keeping this in mind, the Stem cell therapy is growing in popularity globally particularly for neurological disorders and neurodegenerative diseases like Parkinson’s disease. Researchers have confirmed the possibility of development of dopaminergic neurons from human embryonic stem cells, which have the potential to become any cell of the body. Clinics offering stem cell therapy are now [… Read More]
An exciting new discovery on a genetic mutation that appears to be associated with Parkinson’s disease once again brings hope to some PD patients. Parkinson’s disease is gradually progressive neurodegenerative disorder manifested due to the loss of dopamine producing nerve cells, which are predominantly situated in a crescent shaped region of of the brain called as nigro-striatum. The main causes and pathophysiology of Parkinson’s disease is still not well understood. However various familial and genetic factors have been found to play a crucial role in the development of disease. The genes undergo mutations and somehow alter the dopamine related biochemical processes in the brain. One such mutation in the gene known as VPS35, was identified in a large Swiss family with a history of Parkinson’s disease. While this may not be applicable for every case [… Read More]
Parkinson’s disease is a degenerative disease of the brain where there is progressive depletion of dopamine producing neurons in the substantia nigra, located in the brain. Stem cell therapy may possibly offer a solution as it aims at treating this disease by growing new cells to replace the older degenerated ones.