Parkinson’s disease is a movement disorder which occurs in about 1% of the general population above 55 years of age. It manifests as selective damage to the dopaminergic neurons, which are situated in the nigro-striatal region of the brain and leads to motor-deficits which includes rigidity, tremors, dementia, frequent falls, and freezing of gait in the later stages. Dopamine replacement therapy is the most commonly used treatment strategy against PD. However it provides only symptomatic relief and the disease progresses inevitably. Also, as the time goes by, it loses its efficacy along with a substantial increase in the side effects. That being said, it becomes crucial to develop an interventional strategy, which can effectively retard, halt or even reverse the process of disease progression. In this regard, the epidemiological studies over the past 50 years [… Read More]
An exciting new discovery on a genetic mutation that appears to be associated with Parkinson’s disease once again brings hope to some PD patients. Parkinson’s disease is gradually progressive neurodegenerative disorder manifested due to the loss of dopamine producing nerve cells, which are predominantly situated in a crescent shaped region of of the brain called as nigro-striatum. The main causes and pathophysiology of Parkinson’s disease is still not well understood. However various familial and genetic factors have been found to play a crucial role in the development of disease. The genes undergo mutations and somehow alter the dopamine related biochemical processes in the brain. One such mutation in the gene known as VPS35, was identified in a large Swiss family with a history of Parkinson’s disease. While this may not be applicable for every case [… Read More]
Swine flu is a respiratory infection, with symptoms similar to that of the common flu and people living with Parkinson’s disease are at particular risk of developing severe symptoms if infected. Swine flu is caused by a new strain of influenza A virus, called the H1N1 virus. Normally, swine flu is a disease confined to pigs, and transmission to humans is rare, but the new strain has spread rapidly from pigs to humans. In this current pandemic, human-to-human transmission by direct contact (hand to mouth or nose) and by sneezing or coughing.